Division of Molecular Carcinogenesis

Japanese

Introduction:

Aims and policies of our laboratory are to study molecular mechanisms of carcinogenesis and to develop new targeted therapies for malignancies. One of the candidates is neuroblastoma, the most common extracranial solid malignant tumor in childhood.

Key Words: Neuroblastoma, ARF/p16, p53 families, epigenetics Cancer Stem cells, Polycombs

Members:

Head (Director)Takehiko Kamijo

ResearcherHisanori Takenobu

Graduate School of Medicine, Chiba UniversityYohko Yamaguchi

StudentSayaka Yoshida

traineeShintaro Iwata
Hidemasa Ochiai
Nobuhiro Akita
Fahmi Ferdous

Technical AssistantKumiko Sakurai

Representative References:

• Abe M K et al. Pediatric Int 2009 51:103-6
• Kurata K et al. Oncogene 2008; 27:741-54.
• Miki J et al. Genes To Cells. 2007;12:1371-82.
• Nakazawa Y et al. J Biol Chem 2003; 278:27888-95
• Komatsu S et al. Oncogene, 2009; 28:3631-41
• Ochiai H et al. Oncogene 2010; in press.
• Iwata S et al. Cancer Sci 2010; in press.

Research projects:

Our laboratory aims to study molecular mechanisms of carcinogenesis and to develop new targeted therapies for malignancies.

1. Molecular carcinogenesis for development of targeted therapy
2. Stem cells and carcinogenesis/metastasis (collaborative Res Project)
3. p53 family genes and carcinogenesis/metastasis (collaborative Res Project)
4. Translational research of pediatric cancers (collaborative Res Project)

Motivated students will be very welcome to join our research projects. Please contact us by the following address.