p53 Family (p53, p63 & p73) and Carcinogenesis/Metastasis

Japanese

Laboratories participate:

Laboratory of Anti-tumor Research (Toshinori Ozaki, et al)

Laboratory of Innovative (Akira Nakagawara、Nobuko Koshikawa, et al)

Division of Molecular Carcinogenesis (Takehiko Kamijo, et al)

Summary of project:

Our collaborative team is extensively working on unveiling the functional roles of the p53 family members (p53, p63 and p73) in development and carcinogenesis.  We started to work on the p73 gene mapped to chromosome 1p36.2 in 1997 when the discovery of p73 was first published in Cell.  We also discovered the p63 gene in collaboration with Dr. S. Ikawa’s group in 1998.  Now, our data suggest that p63 plays an important role in genesis of childhood cancers.  In addition, the issue of cytoplasmic localization of p53 in neuroblastoma is still an enigma.

The molecules we identified as functionally interacting with p53 include Plk1, NFBD1/MDC1, AICD, NEDL1, NEDL2, AMPK, GDF15, NFkB, 14-3-3s, UFD2, Topors, RACK1, MM1, HMGB1/2, UNC5H4.  We have so far published 51 papers related with p53 family genes.

Keywords:

p53, p63, p73, p19ARF, p16, Rb, c-Myc, MYCN, development, cancer, cell cycle regulation, DNA damage and repair

Recent main publications:

• Okoshi R, etal. J Biol Chem 2008; 283: 3979-3987
• Li Y, et al. Oncogene 2008; 27: 3700-3709
• Nakanishi M et al. J Biol Chem 2007; 282: 22993-23004
• Furuya K etal. J Biol Chem 2007; 282: 18365-18378
• Hanamoto T, et al. J Biol Chem 2005; 280: 16665-16675
• Ando K, et al. J Biol Chem 2004; 279: 25549-25561