1 Members
| Head: |
|
Akira
Nakagawara(Visiting Professor, Chiba University
School of Medicine) |
| Senior
Researcher: |
| Hisashi Tokita |
| Toshinori Ozaki |
| Hajime Kageyama |
| Yohko Nakamura |
| Researcher: |
| Eriko Isogai |
| Miki Ohira |
| Visiting
Research Fellow: |
| Setsuko
Kaneko(Department of Pediatric Surgery, University of Tsukuba School of Medicine) |
| Sayaka Ono (Protein Express Co. Ltd.) |
| Li Yuanyuan (Furukawa Electric Co. Ltd.) |
| Minoru Tomizawa (Department of Tumor, Chiba University School of Medicine) |
| Makoto Suzuki (Department of Thoracic Surgery, Chiba University School of Medicine) |
| Takashi Togawa (Division of Radiation Oncology, Chiba Cancer Center) |
| Toshihiko Iuchi (Division of Neurological Surgery, Chiba Cancer Center) |
| Graduate
Student: |
Hideki Yamamoto (Department of General Surgical Science, Gunma University Graduate
School of Medicine) |
| Kayoko Koide (Department of Pediatrics, Saga University Graduate School of Medicine) |
| Hidetaka Niizuma (Department of Pediatrics, Tohoku University Graduate School of Medicine) |
| Atsushi Kawasaki (Division of Digestive Surgery, Nihon University School of Medicine) |
| Takeshi Furuya (Division of Pediatric Surgery , Nihon University School of Medicine) |
Ken-ichi Inoue (First Department of Surgery, Hokkaido University Graduate School of
Medicine) |
| Yusuke Suenaga (Chiba University Graduate School of Medical and Pharmaceutical Sciences) |
Sang Mei Xiang (Department of Breast Cancer, The First Surgery, The Fourth Clinical
Medical College of Hebei Medical University) |
| Shamim Hossain (Department of Science, Rajshahi University） |
| Youquan Bu (Chongqing University of Medical Sciences) |
Nami Koida (Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral
Health Sciences, Graduate School, Tokyo Medical and Dental University) |
| Toshifumi Hosoda (Division of Pediatric Surgery , Nihon University School of Medicine) |
Wang Hong (Department of Pediatrics, the Second Affiliated Hospital of China Medical
University) |
| Daniel Wetterskog (Department of Anatomy and Cellbiology, Gothenburg University, Sweden) |
| Student: |
| Masahiro Yoshida (Department of Biology, Faculty of Science, Chiba University) |
| Yoshiyuki Yamada (Department of Biology, Faculty of Science, Chiba University) |
| Hiroki Arisato (Chiba University School of Medicine) |
| Masaki Horie (Department of Medical Science, Suzuka University School of Medicine) |
| Takao Sawabe (Tokyo College of Medico Pharmaco Technology) |
| Chika Miyahara (Tokyo College of Medico Pharmaco Technology) |
2 Research Projects
(1). Functional genomics: Comprehensive analysis of genomic aberrations and gene expression profiles in cancers
(2). Molecular mechanism of DNA damage and its repair: Role of p53 and p73
(3). Childhood cancers: Molecular understanding of carcinogenesis and a challenge to the tailor-made medicine
(4). Cancer stem cells: From carcinogenesis research to clinical application
(5). Practical translational research of cancers
3 Selected papers (2002-present)
---Publication List
1. Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira
M, Nakagawara A. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Cancer Res. 65: 4587-4597, 2005
2. Hanamoto T, Ozaki T, Furuya K, Hosoda M, Hayashi S, Nakanishi M, Yamamoto H, Kikuchi H, Todo S, Nakagawara
A. Identification of protein kinase A catalytic subunit (PKA-C) as a novel binding partner of p73 and regulation of p73 function. J. Biol. Chem. 280: 16665-16675, 2005
3. Ohira M, Oba S, Nakamura Y, Isogai E, Kaneko S, Nakagawa A, Hirata T, Kubo H, Goto T, Yamada S, Yoshida Y, Fuchioka M, Ishii S, Nakagawara A. Expression profiling using a tumor-specific cDNA microarray predicts the prognosis of intermediate-risk neuroblastomas. Cancer Cell 7: 337-350, 2005
4. Ando K, Ozaki T, Yamamoto H, Furuya K, Hosoda M, Hayashi S, Fukuzawa M, Nakagawara
A. Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. J. Biol. Chem. 279: 25549-25561, 2004.
5. Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara
A. NEDL1, a novel ubiquitin-protein isopeptide ligase for Dishevelled-1, targets mutant superoxide dismutase-1. J. Biol. Chem. 279: 11327-11335, 2004.
6. Ohira M, Morohashi A, Inuzuka H, Shishikura T, Kawamoto T, Kageyama H, Nakamura Y, Isogai E, Takayasu H, Sakiyama S, Suzuki Y, Sugano S, Goto T, Sato S, Nakagawara
A. Expression profiling and characterization of 4,200 genes cloned from primary neuroblastomas: Identification of 305 genes differentially expressed between favorable and unfavorable subsets. Oncogene 22: 5525-5536, 2003.
7. Watanabe K, Ozaki T, Nakagawa T, Miyazaki K, Takahashi M, Hosoda M, Hayashi S, Todo S, Nakagawara
A. Physical interaction of p73 with c-myc and MM1, a c-myc-binding protein, and modulation of the p73 function. J. Biol. Chem. 277: 15113-15123, 2002.
8. Nakagawa T, Takahashi M, Ozaki T, Watanabe K, Todo S, Mizuguchi H, Hayakawa T, Nakagawara
A. Autoinhibitory regulation of p73 by Np73 to modulate cell survival and death through p73-specific target element within the Np73 promoter. Mol. Cell. Biol. 22: 2575-2585, 2002.
